Angiogenesis: a new physiological role for N-arachidonoyl serine and GPR55?
نویسندگان
چکیده
منابع مشابه
Effect of N-arachidonoyl-l-serine on human cerebromicrovascular endothelium☆
N-arachidonoyl-l-serine (ARA-S) is an endogenous lipid, chemically related to the endocannabinoid, N-arachidonoyl ethanolamine (i.e., anandamide) and with similar physiologic and pathophysiologic functions. Reports indicate that ARA-S possesses vasoactive and neuroprotective properties resembling those of cannabinoids. However, in contrast to cannabinoids, ARA-S binds weakly to its known classi...
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N-arachidonoyl dopamine (NADA) is a member of the family of endocannabinoids to which several other N-acyldopamines belong as well. Their activity is mediated through various targets that include cannabinoid receptors or transient receptor potential vanilloid (TRPV)1. Synthesis and degradation of NADA are not yet fully understood. Nonetheless, there is evidence that NADA plays an important role...
متن کاملN-arachidonoyl L-serine, a putative endocannabinoid, alters the activation of N-type Ca2+ channels in sympathetic neurons.
The effect of N-arachidonoyl l-serine (ARA-S), a recently discovered lipoamino acid found in the CNS, on N-type Ca2+ channels of rat sympathetic ganglion neurons was determined using whole cell patch clamp. Application of ARA-S produced a rapid and reversible augmentation of Ca2+ current that was voltage dependent and resulted from a hyperpolarizing shift in the activation curve. ARA-S did not ...
متن کاملN-Arachidonoyl L-Serine, a Putative Endocannabinoid, Alters the Activation of N-Type Ca Channels in Sympathetic Neurons
Guo J, Williams DJ, Ikeda SR. N-arachidonoyl L-serine, a putative endocannabinoid, alters the activation of N-type Ca channels in sympathetic neurons. J Neurophysiol 100: 1147–1151, 2008. First published January 30, 2008; doi:10.1152/jn.01204.2007. The effect of N-arachidonoyl L-serine (ARA-S), a recently discovered lipoamino acid found in the CNS, on N-type Ca channels of rat sympathetic gangl...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2010
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2010.00788.x